Journal: Frontiers in Pain Research
Article Title: NOP agonist AT-403 promoted sleep in lactic acid-induced acute pain model
doi: 10.3389/fpain.2025.1659121
Figure Lengend Snippet: Effects of AT-403 on locomotor function. The highest dose of AT-403 decreased trial duration (A) and maximum speed/rotations per minute (RPM) reached (B) on the Rotarod task in females (squares) but not males (open circles). No sex differences were detected. Data expressed as the average ± SEM in error bars. * p < 0.05, significant from vehicle.
Article Snippet: To determine whether AT-403 affected locomotor function that could confound interpretation of lactic acid-induced behaviors, we assessed locomotor coordination and balance using the Rotarod task (Med Associates, ENV-571R).
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